Endocrine Abstracts

Background and aim: Sirtuin1 (SIRT1) and sclerostin play important roles in adipose tissue and bone metabolism. SIRT1 pharmacological induction improves bone quality both in murine and human models and- as adiposity increases – its expression decreases both in peripheral tissues and blood. Sclerostin reduces osteoblasts’ differentiation and mineralization and is associated with DMT2, obesity and cardiovascular risk. We evaluated the circulating SIRT1 and sclerostin r...

Introduction: Metabolic surgery is the most effective long-term treatment for obesity. However, studies reveal that up to 40% of post-bariatric subjects experience long-term weight regain (WR), particularly those who discontinue surgical and nutritional follow-ups. In contrast, the ketogenic diet emerges as a pivotal therapy for obesity, showing convincing evidence in weight loss and improvement of weight-related complications.Purpose: This study aims to...

Introduction: Obesity is a chronic disease, significantly influenced by maladaptive eating patterns. Oxytocin (OT), recognized for its central role in regulating energy metabolism and eating behavior, represents a potential link in understanding this intricate relationship.Objective: This study aimed to investigate the potential association between circulating levels of OT and maladaptive eating behaviors, assessed through the Eating Behaviors Assessment...